What Is Delta-8? Safety, Side Effects, and More - GoodRx (2024)

Key takeaways:

  • Delta-8 THC is an active ingredient (cannabinoid) of the cannabis plant. But most delta-8 products are made from converted CBD oil.

  • Delta-THC products have increased in popularity in recent years due to availability and the misconception that they’re less potent, or more ‘natural’ than other forms of THC.

  • The biggest risk of delta-8 THC is that it’s not regulated. This means that the safety, purity, and strength can’t be guaranteed. And the process used to make it can leave harmful chemicals behind. It’s also available over the counter, which makes it easier for minors to access.

  • Until more research is done and stricter regulations are passed, it’s safer to use regulated cannabis products instead of over-the-counter delta-8 products.

Table of contents

Definition

Safety

Delta-8 vs. CBD

Benefits

Side effects

Is it legal

Bottom line

References

What Is Delta-8? Safety, Side Effects, and More - GoodRx (1)

Delta-8 tetrahydrocannabinol (THC) is an active ingredient (cannabinoid) produced by the cannabis plant. It’s often marketed as being a natural cannabis product, but most delta-8 THC is chemically made by adding strong acids to convert CBD oil into delta-8 THC.

Most delta-8 THC products currently being sold are manufactured without following any safety regulations. And, because delta-8 THC isn’t a main component of the cannabis plant, it hasn’t been studied as much as CBD and delta-9 THC. Currently, there are no federal regulations around childproof packaging, laboratory testing, or clear labeling of delta-8 products.

We’ll cover how delta-8 is different from delta-9 THC and CBD, its side effects, and why its safety can’t be guaranteed.

What is delta-8 THC?

Delta-8 THC is one of many chemicals produced by the cannabis plant. These chemicals interact with the human body in different ways.

But Delta-8 THC is considered a minor cannabinoid because it’s only found in very small amounts in cannabis plants. The most common and abundant chemicals in the cannabis plant are delta-9 THC and cannabidiol (CBD).

Delta-8 THC is what’s known as an isomer of delta-9 THC. This means that its chemical structure is almost identical to delta-9 — just one chemical bond is different between the two compounds. Small amounts of delta-9 THC turn into delta-8 THC naturally when the cannabis plant is exposed to light and air.

How is delta-8 made, and is it synthetic?

As we’ve mentioned, naturally occurring delta-8 THC is very rare. But, delta-8 THC can also be made chemically. The most common way to do this is by using hemp-derived CBD oil as the raw material. Strong acids are then used to convert CBD into delta-8 THC. This means that most delta-8 THC is semisynthetic, rather than the “natural” compound it often claims to be.

What does delta-8 do?

Delta-8 THC can cause a similar high to delta-9 THC. Both delta-8 and delta-9 THC produce mind-altering effects. They do this by binding to the cannabinoid receptors, which are special proteins found throughout the brain.

Does delta-8 have THC?

There’s a common misconception that delta-8 THC has less THC than delta-9 THC. But that’s not quite accurate. Technically delta-8 is THC. But, studies do suggest that it may be less potent than delta-9 THC. That’s because delta-8 THC forms weaker bonds with cannabinoid receptors in the brain than delta-9 THC. In fact, delta-8 THC is commonly referred to as “diet weed” and sold as a weaker version of delta-9 THC. Due to lack of regulation, there’s no way to be sure how much THC is in each delta-8 product.

But it is still THC. This means it’s likely to have psychoactive effects and show up on a drug test.

Is delta-8 safe?

The truth is, we don’t have enough information to know for sure. Very little human research has been done on delta-8 THC. But some laboratory and animal studies have shown that delta-8 produces similar effects to delta-9.

In healthy adults, it’s unlikely that delta-8 THC poses a serious danger if it’s produced safely and used responsibly. However, the over-the-counter (OTC) hemp market isn’t currently well regulated. So delta-8 products made from hemp CBD could be contaminated with heavy metals, pesticides, and mold — all of which could make it into your body if you consume them.

What’s even more concerning is that the chemical solvents used to convert CBD into delta-8 THC can be toxic if they aren’t removed properly from the final product (known as residual solvents). Without regulations in place to test and control for these contaminants, there’s no way to guarantee the safety of delta-8 THC products sold OTC.

That said, delta-8 THC use has risks. Between 2021 and 2024, Poison Control Centers received 8,750 calls about delta-8, and emergency room visits have increased. Experts are on the lookout for complications in minors, too. A survey of U.S. high schoolers in 2023 found that more than 11% of 12th graders report delta-8 THC use. In October 2021, the CDC and the FDA put out health warnings about the dangers of delta-8 THC.

However, some states allow the sale of delta-8 THC in licensed cannabis dispensaries after it has passed the same testing requirements as regulated cannabis products. These delta-8 products are less likely to be unsafe than their OTC counterparts.

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How does delta-8 compare to CBD?

Delta-8 THC has very little in common with CBD, other than the fact that CBD is used to make it. Delta-8 THC and CBD work very differently in the body. CBD doesn’t cause the same “high” that delta-8 and delta-9 THC do. But since delta-8 THC is often sold as delta-8 hemp or delta-8 CBD, this can be very confusing and misleading when you’re buying it.

What are the potential benefits of delta-8 THC?

Although there’s limited data available, delta-8 may be able to provide the same benefits as delta-9 THC but with less psychoactivity. So it may be helpful for people who want to use THC to manage nausea, pain, or insomnia but want to avoid the euphoria that comes with delta-9 THC. But more research needs to be done. And we also need better regulation to ensure that delta-8 THC products are produced safely.

Delta-8 side effects and risks

Because it’s easy to confuse delta-8 with hemp or CBD products (which typically don’t cause euphoria), many people accidentally consume too much, not expecting to get high. This may cause side effects, which can be particularly troubling if you aren’t prepared for them. Effects can include:

  • Experiencing fear, anxiety, or panic

  • Struggling with body coordination

  • Not thinking clearly

  • Seeing or hearing things that aren’t really there

  • Having irrational thoughts or feeling like you’re not yourself

If you do decide to try delta-8 THC, it’s best to start with a small dose to see how it will affect you. Increase your dose slowly over time to allow your body to adjust and avoid negative side effects. Don’t drive or operate machinery on delta-8. Keep in mind, these products are not appropriate for children or adolescents.

What to do if you have severe side effects from delta-8 THC

If you experience any of the symptoms listed above, rest assured that they’re usually temporary. Keep in mind that if you’ve accidentally taken too much delta-8 THC in edible form, it could take several hours to feel normal again. It’s best to stay calm and use self-care techniques while you wait for the effects to wear off.

However, if you’re having difficulty breathing, chest pain, or any other serious concerns, it’s important to call 911 or go to the emergency room. Other serious side effects could be due to residual solvents or contamination.

How much delta-8 is safe to consume?

If it isn’t from a regulated dispensary, there’s no safe amount of delta-8 to consume. But more research is needed to understand what a standard dose of even regulated delta-8 products should be.

Because the widespread use of delta-8 is so new, it’s too soon to know how addictive it is. However, given its similar effects with delta-9 THC and the way it interacts with the brain, it’s very likely that delta-8 carries all the same risks as cannabis use, including the risk for dependence and addiction.

Similar to cannabis, there are some serious risks of delta-8 THC use in some specific populations, including:

It’s best to avoid delta-8 THC altogether if you fall into one of these groups.

Is delta-8 THC legal?

In short, it’s complicated. In 2018, Congress passed the farm bill, which legalized chemicals derived from hemp. So, as long as a delta-8 product uses hemp-derived CBD as the raw material, it’s technically federally legal.

But most people see this as a “loophole” that uses the farm bill in ways it wasn’t intended. The surge in delta-8 THC production seems to be a way for hemp CBD companies to sell an OTC hemp-based product that makes people feel “high.” Without safety measures in place, it’s also putting people at risk.

In response, several states have banned the sale of delta-8 THC products, citing concerns over public health and safety.

How do you know if you’ve bought delta-8 THC?

Delta-8 products are most commonly sold online, in tobacco shops, and in states where cannabis is illegal. You can find it in vape cartridges, edibles, and capsules, as well as tinctures. Delta-8 oil can even be sprayed on a hemp CBD flower.

The packaging and labeling of delta-8 products can be very confusing and misleading. If you see a product being sold as any of the following, you’re probably looking at a delta-8 THC product:

  • Diet weed

  • Light cannabis

  • Delta-8 hemp

  • Delta-8 CBD

  • Something that gives a “legal high”

The bottom line

The delta-8 molecule itself is likely no more dangerous than regular delta-9 THC. But harmful toxins can get left behind in the product as a result of the chemical processes that make delta-8. And, because delta-8 THC currently exists in a legal gray area, you don’t get any of the benefits that you would with regulated cannabis products. That means there’s no lab testing, accurate labeling, childproof packaging, or any other basic safety assurances. In other words, the manufacturing of delta-8 products leaves a lot of room for error and accidental poisoning.

Delta-9 THC and delta-8 THC products sold at state-licensed dispensaries are regulated. They are currently a safer choice than OTC delta-8 products. More research and tighter regulations are needed before considering OTC delta-8 products safe to consume.

If you or someone you know struggles with substance use, help is available. Call SAMHSA’s National Helpline at 1-800-662-HELP (4357) to learn about resources in your area.

References

America’s Poison Centers. (2024). Delta-8 THC.

Babalonis, S., et al. (2021). Δ8 -THC: Legal status, widespread availability, and safety concerns. Cannabis and Cannabinoid Research.

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Centers for Disease Control and Prevention. (2021). Increases in availability of cannabis products containing delta-8 THC and reported cases of adverse events.

Govaerts, S. J., et al. (2004). Comparison of cannabinoid ligands affinities and efficacies in murine tissues and in transfected cells expressing human recombinant cannabinoid receptors. European Journal of Pharmaceutical Sciences.

Harlow, A. F., et al. (2024). Adolescent Δ8-THC and marijuana use in the US. JAMA.

Johnson-Arbor, K. (2021). What is delta-8 THC? National Capital Poison Center.

Kaufman, A. (2023). Is delta-8 THC legal? Here's where (and why) the hemp product skirts marijuana laws. USA Today.

Kruger, J., et. al. (2022) Delta-8 THC: Delta-9-THC’s nicer younger sibling? Journal of Cannabis Research.

Marzullo, P., et al. (2020). Cannabidiol as the substrate in acid-catalyzed intramolecular cyclization. Journal of Natural Products.

National Institute of Food and Agriculture. (n.d.). Industrial hemp. United States Department of Agriculture.

Paviour, B. (2022). States look to regulate weed alternatives like delta-8 as sales explode. NPR.

Schuba, T. (2021). Feds issue warnings about ‘diet weed’ as Illinois lawmakers try again to crack down on hemp derivative. Chicago Sun-Times.

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Soult, A. (2024). Isomers. University of Kentucky CHE 103: Chemistry for Allied Health.

Stempfer, M., et al. (2021). Analysis of cannabis seizures by non-targeted liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis.

Tagen, M., et al. (2022). Review of delta-8-tetrahydrocannabinol (Δ8-THC): Comparative pharmacology with Δ9-THC. British Journal of Pharmacology.

U.S. Food and Drug Administration. (2022). 5 things to know about delta-8 tetrahydrocannabinol – delta-8 THC.

Wakshlag, J. J., et al. (2020). Cannabinoid, terpene, and heavy metal analysis of 29 over-the-counter commercial veterinary hemp supplements. Veterinary Medicine: Research and Reports.

Wiley, J. L., et al. (1995). Pharmacological specificity of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rhesus monkeys. Drug and Alcohol Dependence.

Yakowicz, W. (2021). Delta-8 THC offers a legal high, but here's why the booming business may soon go up in smoke. Forbes.

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GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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What Is Delta-8? Safety, Side Effects, and More - GoodRx (2024)

FAQs

Does delta-8 have health risks? ›

In 2022, the U.S. Food and Drug Administration issued a consumer update warning of the serious health risks associated with use of delta-8 THC, including reports of adverse events involving use of delta-8 products and risks of exposure to toxic byproducts.

What happens if you take delta-8 everyday? ›

Consuming delta-8 can lead to many unintended side effects, including psychosis. Psychosis can occur due to the regular consumption of cannabis products and can even trigger long-lasting mental health conditions.

What is the safest delta-8 brand? ›

#1.

The brand sources its hemp from premium farms in Colorado, ensuring all products are organic, non-GMO, and free of artificial additives. Exhale Wellness is highly rated by customers as the best Delta 8 brand across several public forums.

What does the FDA say about delta-8? ›

While the FDA hasn't made any broad recommendations on delta-8 THC, but it has issued individual warnings to companies selling delta-8 THC in ways that violate the Federal Food, Drug, and Cosmetic Act, for example by making claims that delta-8 can treat medical conditions.

Can delta-8 cause permanent damage? ›

But an Emory doctor warns just one high from Delta-8 can cause permanent damage to your child's brain.

Is delta-8 safe for your brain? ›

However, given its similar effects with delta-9 THC and the way it interacts with the brain, it's very likely that delta-8 carries all the same risks as cannabis use, including the risk for dependence and addiction.

Can delta-8 affect your heart? ›

Reported reactions to delta-8 THC include:

Disorientation. Lack of coordination. Increased heart rate progressing to slow heart rate. Sedation.

Can delta-8 cause liver damage? ›

Delta-8 can lead to long-term mental health conditions and affect a person's physical health. Synthetically producing delta-8 can involve many harmful chemicals that can damage the liver, cause cardiac problems, and much more.

Does delta-8 raise blood pressure? ›

Intravenous administration of delta8- and delta9-THC produced dose-related transient increases in blood pressure followed by more prolonged hypotensive responses and bradycardia.

Who should not take delta-8? ›

It is important for consumers to be aware that delta-8 THC products have not been evaluated or approved by the FDA for safe use in any context. They may be marketed in ways that put the public health at risk and should especially be kept out of reach of children and pets.

What is better than delta-8? ›

It is thought that delta-10 THC has greater potency than delta-8 THC. The cannabinoid's increased ability to affect the cannabinoid receptors produces a stronger psychoactive effect. However, a person's tolerance and the mode of consumption can both affect how potent delta-8 THC is.

What company has the strongest delta-8? ›

  1. Elevate – Overall Best Delta 8 Brand: Top Rated. ...
  2. Binoid – Most Potent Brand to Buy Delta 8 Products. ...
  3. Diamond CBD – Positive Reviews for Delta 8 THC Products. ...
  4. Delta ExtraX – Reputable Delta 8 brand for Hemp Products. ...
  5. Moonwlkr – Recommended THC Brand for Delta 8 Edibles. ...
  6. Mystic Labs – Trusted Delta 8 THC Brand.
Mar 29, 2024

Does delta 8 have side effects? ›

While it doesn't produce as intense a high as delta-9 THC, delta-8 can affect your mood, thoughts, feelings, and how you act. In fact, delta-8 is often referred to as “marijuana lite” or “diet weed.” Other common THC side effects like paranoia, anxiety, and drowsiness are also less potent with delta-8 than delta-9.

How long does Delta 8 stay in your system? ›

So they can accumulate over time with regular use. Because their structures are similar, delta-8 is expected to stay in the body for the same amount of time as delta-9 THC. For occasional users, this could be as little as 2 to 5 days. For regular users, it could be up to 15 days.

Why isn t delta-8 safe? ›

FDA has not evaluated or approved delta-8 THC products for safe use. Since Delta-8 THC is found in such small quantities in the cannabis plant, it is often chemically made from CBD. As such, these products may contain other cannabinoids, terpenes, or chemical contaminants that are not on the product label.

Does delta-8 weaken immune system? ›

Δ-8-THC has been shown to induce immune system homeostasis particularly in individuals with autoimmune disorders by reducing the activity of T cells and B cells.

Is delta-8 natural or synthetic? ›

Delta-8 occurs naturally in small quantities in cannabis, however most of the commercially available delta-8 has been synthesized through a conversion process that uses a variety of chemicals to convert hemp-derived CBD into delta-8.

References

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